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Analysis of institutional authors

Oliver-De La Cruz, JorgeAuthor
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Article

Regulation of Cell-Nanoparticle Interactions through Mechanobiology

Publicated to:Nano Letters. 25 (7): 2600-2609 - 2025-01-08 25(7), DOI: 10.1021/acs.nanolett.4c04290

Authors: Cassani, M; Niro, F; Fernandes, S; Pereira-Sousa, D; Morazzo, SF; Durikova, H; Wang, TZ; González-Cabaleiro, L; Vrbsky, J; Oliver-De La Cruz, J; Klimovic, S; Pribyl, J; Loja, T; Skladal, P; Caruso, F; Forte, G

Affiliations

Barcelona Inst Sci & Technol BIST, Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain - Author
CEITEC Masaryk Univ, Mol Med, Brno 62500, Czech Republic - Author
CEITEC Masaryk Univ, Nanobiotechnol Core Facil, Brno 62500, Czech Republic - Author
Cellular and Molecular Mechanobiology. Institute for Bioengineering of Catalonia - Author
Kings Coll London, Sch Cardiovasc & Metab Med & Sci, London WC2R 2LS, England - Author
Masaryk Univ, Fac Med, Dept Biomed Sci, Brno 62500, Czech Republic - Author
Masaryk Univ, Fac Sci, Dept Biochem, Brno 62500, Czech Republic - Author
St Annes Univ Hosp, Int Clin Res Ctr, Brno 65691, Czech Republic - Author
Univ Melbourne, Dept Chem Engn, Parkville, Vic 3010, Australia - Author
Univ Vigo, Campus Univ Lagoas Marcosende, Dept Qui?m Fi?s, Vigo 36310, Spain - Author
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Abstract

Bio-nano interactions have been extensively explored in nanomedicine to develop selective delivery strategies and reduce systemic toxicity. To enhance the delivery of nanocarriers to cancer cells and improve the therapeutic efficiency, different nanomaterials have been developed. However, the limited clinical translation of nanoparticle-based therapies, largely due to issues associated with poor targeting, requires a deeper understanding of the biological phenomena underlying cell-nanoparticle interactions. In this context, we investigate the molecular and cellular mechanobiology parameters that control such interactions. We demonstrate that the pharmacological inhibition or the genetic ablation of the key mechanosensitive component of the Hippo pathway, i.e., yes-associated protein, enhances nanoparticle internalization by 1.5-fold. Importantly, this phenomenon occurs independently of nanoparticle properties, such as size, or cell properties such as surface area and stiffness. Our study reveals that the internalization of nanoparticles in target cells can be controlled by modulating cell mechanosensing pathways, potentially enhancing nanotherapy specificity.

Keywords
Bio-nano interactionsCompleMechanobiologyMechanotransductioNanoparticlesYap/taz

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nano Letters due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 24/141, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Physical.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-24:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia; Czech Republic; United Kingdom.