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Analysis of institutional authors

Gómez-González MCorresponding AuthorLatorre EAuthorArroyo MCorresponding AuthorTrepat XCorresponding Author
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Review

Measuring mechanical stress in living tissues

Publicated to:Nature Reviews Physics. 2 (6): 300-317 - 2020-06-01 2(6), DOI: 10.1038/s42254-020-0184-6

Authors: Gómez-Gonzalez, M; Latorre, E; Arroyo, M; Trepat, X

Affiliations

Barcelona Inst Sci & Technol BIST, Inst Bioengn Catalonia IBEC, Barcelona, Spain - Author
CIBER Bioingenieria, Biomateriales y Nanomedicina - Author
Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona, Spain - Author
Inst Catalana Recerca Estudis Avancats ICREA, Barcelona, Spain - Author
Institució Catalana de Recerca i Estudis Avançats - Author
Institute for Bioengineering of Catalonia - Author
Instituto de Bioingeniería de Cataluña - Author
Integrative Cell and Tissue Dynamics. Institute for Bioengineering of Catalonia - Author
RA_Theory and computation for cell and tissue mechanics. Institute for Bioengineering of Catalonia - Author
Univ Barcelona, Unitat Biofis & Bioengn, Barcelona, Spain - Author
Univ Politecn Catalunya BarcelonaTech, LaCaN, Barcelona, Spain - Author
Universitat de Barcelona - Author
Universitat Politècnica de Catalunya - Author
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Abstract

© 2020, Springer Nature Limited. Living tissues are active, multifunctional materials capable of generating, sensing, withstanding and responding to mechanical stress. These capabilities enable tissues to adopt complex shapes during development, to sustain those shapes during homeostasis and to restore them during healing and regeneration. Abnormal stress is associated with a broad range of pathological conditions, including developmental defects, inflammatory diseases, tumour growth and metastasis. A number of techniques are available to measure mechanical stress in living tissues at cellular and subcellular resolution. 2D techniques that map stress in cultured cell monolayers provide the highest resolution and accessibility, and include 2D traction force microscopy, micropillar arrays, monolayer stress microscopy and monolayer stretching between flexible cantilevers. Mapping stresses in tissues cultured in 3D can be achieved using 3D traction force microscopy and the microbulge test. Techniques for measuring stress in vivo include servo-null methods for measuring luminal pressure, deformable inclusions, Förster resonance energy transfer tension sensors, laser ablation and computational methods for force inference. Although these techniques are far from becoming everyday tools in biomedical laboratories, their rapid development is fostering key advances in our understanding of the role of mechanics in morphogenesis, homeostasis and disease.

Keywords
AdhesionCell-shapeE-cadherinEpithelial monolayersFinite-elementLaser microsurgeryMigrationPressureTensionTraction force microscopy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nature Reviews Physics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 4/160, thus managing to position itself as a Q1 (Primer Cuartil), in the category Physics, Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 4.09. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 6.53 (source consulted: FECYT Feb 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-23, the following number of citations:

  • WoS: 93
  • Scopus: 94
  • OpenCitations: 91
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 282.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 281 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 45.65.
  • The number of mentions on the social network Facebook: 4 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 82 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/180974
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Gómez González, Manuel) and Last Author (Trepat, Xavier).

the authors responsible for correspondence tasks have been Gómez González, Manuel, Arroyo Balaguer, Marino and Trepat, Xavier.